Full size image. The model also predicts that autistic females will have, in general, lower IQs than autistic males A schematic illustration is given in Figure 2. Accordingly, a genetic mechanism is thought to be responsible for the strong familiality.
The genetic locus is silenced when it is transmitted by a mother and is switched on when transmitted by a father. World Health OrganizationGeneva. Note that the mean ability in the domain illustrated in Figure 3 i is lower in both groups of Turner's females than normal females 3 ii.
Uniparental disomy of the entire X chromosome in a female with Duchenne muscular dystrophy. The table is not all-inclusive, but it provides enough data to show the greater severity of these diseases in males, and to illustrate why some, but not all, females with the same X-linked deleterious allele are protected from its effects.
A nongenetic explanation for male vulnerability, such as exposure to prenatal androgens, is unlikely for a variety of reasons. Shin J. Sex differences in the prevalence of autism have been described in both singleton sex linked sex influenced and sex limited in Baltimore multiplex families 1 — 4.
Ann Hum Genet 61 : —
Lord C, Rutter M, LeCouteur A Autism Diagnostic Interview revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Johns Hopkins University Press, Baltimore.
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